ISSN 1119-4618
 
2022, Vol: 22, Issue: 4
22/4Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Original Research 
JPAS. 2022; 22(4): 623-630


Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay

M. B. Biallah, O. O. Okubanjo, P. A. Abdu, G. A. Dogo, P. D. Kaze.

Abstract
Vernonia amygdalina is one of the plants that have been evaluated for its anticoccidial efficacy in broiler chickens, yet no toxicological profile of its safe use has been investigated. The aim of the study was evaluate the oral acute toxicity in order to determine its safety in the management of avian coccidiosis. The leaves of V. amygdalina were powdered and subjected to methanol extraction using Soxlet apparatus and subsequently partitioned to obtain hexane, butanol, and aqueous residue fractions. A total 25 broiler chickens at 3 weeks of age were divided into 5 groups each of 5 chickens. A single dose of 2,000 mg/kg of suspension of the extracts was administered to the birds in each group; distilled water was given to the control. Clinical signs, gross pathology, histopatholgy, and serum biochemical parameters were determined. The phytochemicals found in the leaves are alkaloids, flavonoids, saponins, tannins, and phenols. The study revealed that the plant is of low toxicity in broiler chickens with an LD50 above 2,000 mg/kg.

Key words: Acute toxicity, methanolic extract, Vernonia amygdalina leaf, broiler chickens


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by M. B. Biallah
Articles by O. O. Okubanjo
Articles by P. A. Abdu
Articles by G. A. Dogo
Articles by P. D. Kaze
on Google
on Google Scholar

How to Cite this Article
Pubmed Style

Biallah MB, Okubanjo OO, Abdu PA, Dogo GA, Kaze PD. Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay. JPAS. 2022; 22(4): 623-630.

Web Style

Biallah MB, Okubanjo OO, Abdu PA, Dogo GA, Kaze PD. Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay. https://www.atbuscienceforum.com/?mno=133330 [Access: January 16, 2023].

AMA (American Medical Association) Style

Biallah MB, Okubanjo OO, Abdu PA, Dogo GA, Kaze PD. Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay. JPAS. 2022; 22(4): 623-630.


Vancouver/ICMJE Style

Biallah MB, Okubanjo OO, Abdu PA, Dogo GA, Kaze PD. Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay. JPAS. (2022), [cited January 16, 2023]; 22(4): 623-630.


Harvard Style

Biallah, M. B., Okubanjo, . O. O., Abdu, . P. A., Dogo, . G. A. & Kaze, . P. D. (2022) Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay. JPAS, 22 (4), 623-630.


Turabian Style

Biallah, M. B., O. O. Okubanjo, P. A. Abdu, G. A. Dogo, and P. D. Kaze. 2022. Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay. Science Forum (Journal of Pure and Applied Sciences), 22 (4), 623-630.


Chicago Style

Biallah, M. B., O. O. Okubanjo, P. A. Abdu, G. A. Dogo, and P. D. Kaze. "Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay." Science Forum (Journal of Pure and Applied Sciences) 22 (2022), 623-630.


MLA (The Modern Language Association) Style

Biallah, M. B., O. O. Okubanjo, P. A. Abdu, G. A. Dogo, and P. D. Kaze. "Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay." Science Forum (Journal of Pure and Applied Sciences) 22.4 (2022), 623-630. Print.


APA (American Psychological Association) Style

Biallah, M. B., Okubanjo, . O. O., Abdu, . P. A., Dogo, . G. A. & Kaze, . P. D. (2022) Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay. Science Forum (Journal of Pure and Applied Sciences), 22 (4), 623-630.


Author LoginReviewer LoginLicense Information
This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access.
The articles in Science Forum (Journal of Pure and Applied Sciences) are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Copyright © 2023 Science Forum (Journal of Pure and Applied Sciences) All Rights Reserved. Subject to change without notice from or liability to Science Forum (Journal of Pure and Applied Sciences).
For best results, please use Internet Explorer or Google Chrome

Contact Information