ISSN 1119-4618
 
2022, Vol: 22, Issue: 4
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Original Research 
JPAS. 2022; 22(4): 623-630


Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay

M. B. Biallah, O. O. Okubanjo, P. A. Abdu, G. A. Dogo, P. D. Kaze.

Abstract
Vernonia amygdalina is one of the plants that have been evaluated for its anticoccidial efficacy in broiler chickens, yet no toxicological profile of its safe use has been investigated. The aim of the study was evaluate the oral acute toxicity in order to determine its safety in the management of avian coccidiosis. The leaves of V. amygdalina were powdered and subjected to methanol extraction using Soxlet apparatus and subsequently partitioned to obtain hexane, butanol, and aqueous residue fractions. A total 25 broiler chickens at 3 weeks of age were divided into 5 groups each of 5 chickens. A single dose of 2,000 mg/kg of suspension of the extracts was administered to the birds in each group; distilled water was given to the control. Clinical signs, gross pathology, histopatholgy, and serum biochemical parameters were determined. The phytochemicals found in the leaves are alkaloids, flavonoids, saponins, tannins, and phenols. The study revealed that the plant is of low toxicity in broiler chickens with an LD50 above 2,000 mg/kg.

Key words: Acute toxicity, methanolic extract, Vernonia amygdalina leaf, broiler chickens


 
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How to Cite this Article
Pubmed Style

Biallah MB, Okubanjo OO, Abdu PA, Dogo GA, Kaze PD. Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay. JPAS. 2022; 22(4): 623-630.

Web Style

Biallah MB, Okubanjo OO, Abdu PA, Dogo GA, Kaze PD. Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay. https://www.atbuscienceforum.com/?mno=133330 [Access: May 27, 2023].

AMA (American Medical Association) Style

Biallah MB, Okubanjo OO, Abdu PA, Dogo GA, Kaze PD. Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay. JPAS. 2022; 22(4): 623-630.


Vancouver/ICMJE Style

Biallah MB, Okubanjo OO, Abdu PA, Dogo GA, Kaze PD. Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay. JPAS. (2022), [cited May 27, 2023]; 22(4): 623-630.


Harvard Style

Biallah, M. B., Okubanjo, . O. O., Abdu, . P. A., Dogo, . G. A. & Kaze, . P. D. (2022) Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay. JPAS, 22 (4), 623-630.


Turabian Style

Biallah, M. B., O. O. Okubanjo, P. A. Abdu, G. A. Dogo, and P. D. Kaze. 2022. Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay. Science Forum (Journal of Pure and Applied Sciences), 22 (4), 623-630.


Chicago Style

Biallah, M. B., O. O. Okubanjo, P. A. Abdu, G. A. Dogo, and P. D. Kaze. "Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay." Science Forum (Journal of Pure and Applied Sciences) 22 (2022), 623-630.


MLA (The Modern Language Association) Style

Biallah, M. B., O. O. Okubanjo, P. A. Abdu, G. A. Dogo, and P. D. Kaze. "Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay." Science Forum (Journal of Pure and Applied Sciences) 22.4 (2022), 623-630. Print.


APA (American Psychological Association) Style

Biallah, M. B., Okubanjo, . O. O., Abdu, . P. A., Dogo, . G. A. & Kaze, . P. D. (2022) Acute toxicity study of methanolic extract of Vernonia amygdalina leaf and its fractions in broiler chickens, as a prelude to its anticoccidial efficacy assay. Science Forum (Journal of Pure and Applied Sciences), 22 (4), 623-630.


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