ISSN 1119-4618
 

Original Research 


CHEMO-SUPPRESSIVE AND CURATIVE ANTIMALARIAL BIOACTIVE POTENTIALS OF ALBIZIA CHEVALIER METHANOLIC LEAF EXTRACT

Hajara Sani Labaran, Ummu Rabiu R.A, Abdulwahab Aliyu, Samaila A.B, Samaila A.B, kwaya B.V, Ndukwe Nelson Nwanchukwu.

Abstract
Malaria a serious cause for concern due to the harmit causes to humanity including death and morbidity in the tropical countries. The crude mixture of phyto-constituents extracted from leaf of Albizia chevalieri using methanol was assessed for potential chemo-suppresive anti-plasmodial bio-activity during early and established infections. Plasmodium berghei NK64 with resistance to chloroquine wasused to check for the anti plasmodial activity of the extract. Albino wistar rats were treated with artemeter 80mg/kg/body weight, as the standard drug, group II were treated with 0.2ml of normal saline, group III, IV, V and VI, were treated 100, 200, 400 and 800mg/kg body weight of the test item(extract) respectively, the blood level of parasite, mean survival time and change in weight of the rats were used to demonstrate the bio-antimalarial potency of the crude extract. The secondary metabolite from leaf extract have shown a significant (P<0.01) dose-dependent bioactive potency against the parasite in the 4-days suppressive and curative test. The antimalarial pharmacological bioactivity ofA.chevalieri was almost similar to that produced by artermether. The leaf crude extract similarly extended the endurance period of the Plasmodium berghei infected rats. This finding indicated that the extract form leaf of Albizia chevalieri possessed potential antiparasitic antiplasmodial bioactivity, that can be exploited in malaria pharmacotherapy.Similarly with further laboratory investigation, Albizia chevalieri could serve as a potential lead itemfor new and novel antimalarial drug for the treatment and control of malaria.

Key words: chemo-suppression, curative, Albizia, berghei, infections, parasitemia


 
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How to Cite this Article
Pubmed Style

Labaran HS, R.A UR, AA, SA, SA, kB, Nwanchukwu NN, . CHEMO-SUPPRESSIVE AND CURATIVE ANTIMALARIAL BIOACTIVE POTENTIALS OF ALBIZIA CHEVALIER METHANOLIC LEAF EXTRACT . JPAS. 2020; 20(3): 260-265. doi:10.5455/sf.79911


Web Style

Labaran HS, R.A UR, AA, SA, SA, kB, Nwanchukwu NN, . CHEMO-SUPPRESSIVE AND CURATIVE ANTIMALARIAL BIOACTIVE POTENTIALS OF ALBIZIA CHEVALIER METHANOLIC LEAF EXTRACT . http://www.atbuscienceforum.com/?mno=79911 [Access: August 10, 2020]. doi:10.5455/sf.79911


AMA (American Medical Association) Style

Labaran HS, R.A UR, AA, SA, SA, kB, Nwanchukwu NN, . CHEMO-SUPPRESSIVE AND CURATIVE ANTIMALARIAL BIOACTIVE POTENTIALS OF ALBIZIA CHEVALIER METHANOLIC LEAF EXTRACT . JPAS. 2020; 20(3): 260-265. doi:10.5455/sf.79911



Vancouver/ICMJE Style

Labaran HS, R.A UR, AA, SA, SA, kB, Nwanchukwu NN, . CHEMO-SUPPRESSIVE AND CURATIVE ANTIMALARIAL BIOACTIVE POTENTIALS OF ALBIZIA CHEVALIER METHANOLIC LEAF EXTRACT . JPAS. (2020), [cited August 10, 2020]; 20(3): 260-265. doi:10.5455/sf.79911



Harvard Style

Labaran, H. S., R.A, U. R., , A. A., , S. A., , S. A., , k. B., Nwanchukwu, N. N. & (2020) CHEMO-SUPPRESSIVE AND CURATIVE ANTIMALARIAL BIOACTIVE POTENTIALS OF ALBIZIA CHEVALIER METHANOLIC LEAF EXTRACT . JPAS, 20 (3), 260-265. doi:10.5455/sf.79911



Turabian Style

Labaran, Hajara Sani, Ummu Rabiu R.A, Abdulwahab Aliyu, Samaila A.B, Samaila A.B, kwaya B.V, Ndukwe Nelson Nwanchukwu, and . 2020. CHEMO-SUPPRESSIVE AND CURATIVE ANTIMALARIAL BIOACTIVE POTENTIALS OF ALBIZIA CHEVALIER METHANOLIC LEAF EXTRACT . Science Forum (Journal of Pure and Applied Sciences), 20 (3), 260-265. doi:10.5455/sf.79911



Chicago Style

Labaran, Hajara Sani, Ummu Rabiu R.A, Abdulwahab Aliyu, Samaila A.B, Samaila A.B, kwaya B.V, Ndukwe Nelson Nwanchukwu, and . "CHEMO-SUPPRESSIVE AND CURATIVE ANTIMALARIAL BIOACTIVE POTENTIALS OF ALBIZIA CHEVALIER METHANOLIC LEAF EXTRACT ." Science Forum (Journal of Pure and Applied Sciences) 20 (2020), 260-265. doi:10.5455/sf.79911



MLA (The Modern Language Association) Style

Labaran, Hajara Sani, Ummu Rabiu R.A, Abdulwahab Aliyu, Samaila A.B, Samaila A.B, kwaya B.V, Ndukwe Nelson Nwanchukwu, and . "CHEMO-SUPPRESSIVE AND CURATIVE ANTIMALARIAL BIOACTIVE POTENTIALS OF ALBIZIA CHEVALIER METHANOLIC LEAF EXTRACT ." Science Forum (Journal of Pure and Applied Sciences) 20.3 (2020), 260-265. Print. doi:10.5455/sf.79911



APA (American Psychological Association) Style

Labaran, H. S., R.A, U. R., , A. A., , S. A., , S. A., , k. B., Nwanchukwu, N. N. & (2020) CHEMO-SUPPRESSIVE AND CURATIVE ANTIMALARIAL BIOACTIVE POTENTIALS OF ALBIZIA CHEVALIER METHANOLIC LEAF EXTRACT . Science Forum (Journal of Pure and Applied Sciences), 20 (3), 260-265. doi:10.5455/sf.79911