ISSN 1119-4618
 

Original Research 


Sub-acute Toxicity Potentials of Albizia chevalieri Extracts on the Histology of the Liver, Kidney and Pancreas using Animal Model

Hajara Sani Labaran.

Abstract
Medicinal plants are used in the treatment of many kinds of ailments in traditional medicine. The aim of this study was to investigate the sub-acute toxicity as well as the histological effect of Albizia chevalieri on liver, kidney, pancrease. The sub-acute toxicity study was conducted for 28 days to examine the toxicity of the extracts and the histology of the ratís liver, kidney and pancreas. For this study, fresh set of healthy adult of rats of both sexes were used and grouped in to 4 groups of 5 rats each for methanolic extracts and they were labeled accordingly, group 1 received oral dose of 2000 mg/kg body weight, group 2 received 2500 mg/kg body weight, group 3 received 3000 mg/kg body weight and group 4 received 5000 mg/kg body weight per day, respectively, for 28 days using oral gavagesí. Clinical observation was carried out for 28 days and their weight were measured weekly for four weeks. On the 28th day the final weight of the rats were measured and then they were anesthetized under diethyl ether the rats were sacrificed and the tissues were preserved in formal saline for histological examinations. The sub-acute toxicity study of the rats showed no significant change on behavior. The methanol extracts of Albizia chevalieri does not produce adverse effects in rats after the sub-acute treatment. Chronic and sub-chronic toxicity evaluations need to be done before marketing Albizia chevalieri.

Key words: sub-acute, Treatment, histology, mortality


 
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How to Cite this Article
Pubmed Style

Hajara Sani Labaran. Sub-acute Toxicity Potentials of Albizia chevalieri Extracts on the Histology of the Liver, Kidney and Pancreas using Animal Model. JPAS. 2021; 21(1): 201-205. doi:10.5455/sf.69191


Web Style

Hajara Sani Labaran. Sub-acute Toxicity Potentials of Albizia chevalieri Extracts on the Histology of the Liver, Kidney and Pancreas using Animal Model. http://www.atbuscienceforum.com/?mno=69191 [Access: May 21, 2021]. doi:10.5455/sf.69191


AMA (American Medical Association) Style

Hajara Sani Labaran. Sub-acute Toxicity Potentials of Albizia chevalieri Extracts on the Histology of the Liver, Kidney and Pancreas using Animal Model. JPAS. 2021; 21(1): 201-205. doi:10.5455/sf.69191



Vancouver/ICMJE Style

Hajara Sani Labaran. Sub-acute Toxicity Potentials of Albizia chevalieri Extracts on the Histology of the Liver, Kidney and Pancreas using Animal Model. JPAS. (2021), [cited May 21, 2021]; 21(1): 201-205. doi:10.5455/sf.69191



Harvard Style

Hajara Sani Labaran (2021) Sub-acute Toxicity Potentials of Albizia chevalieri Extracts on the Histology of the Liver, Kidney and Pancreas using Animal Model. JPAS, 21 (1), 201-205. doi:10.5455/sf.69191



Turabian Style

Hajara Sani Labaran. 2021. Sub-acute Toxicity Potentials of Albizia chevalieri Extracts on the Histology of the Liver, Kidney and Pancreas using Animal Model. Science Forum (Journal of Pure and Applied Sciences), 21 (1), 201-205. doi:10.5455/sf.69191



Chicago Style

Hajara Sani Labaran. "Sub-acute Toxicity Potentials of Albizia chevalieri Extracts on the Histology of the Liver, Kidney and Pancreas using Animal Model." Science Forum (Journal of Pure and Applied Sciences) 21 (2021), 201-205. doi:10.5455/sf.69191



MLA (The Modern Language Association) Style

Hajara Sani Labaran. "Sub-acute Toxicity Potentials of Albizia chevalieri Extracts on the Histology of the Liver, Kidney and Pancreas using Animal Model." Science Forum (Journal of Pure and Applied Sciences) 21.1 (2021), 201-205. Print. doi:10.5455/sf.69191



APA (American Psychological Association) Style

Hajara Sani Labaran (2021) Sub-acute Toxicity Potentials of Albizia chevalieri Extracts on the Histology of the Liver, Kidney and Pancreas using Animal Model. Science Forum (Journal of Pure and Applied Sciences), 21 (1), 201-205. doi:10.5455/sf.69191