ISSN 1119-4618
 

Original Research 


The effect of thiamethoxam and ameliorative property of quercetin on oxidative stress and antioxidant parameters in liver of male rats

Mohammed Shuaibu Auwal, Kumar Vinod, Sabo Isa Salihu, Kant Vinay, Bhidhasra Aryan.

Abstract
Studies on subchronic toxicity of thiamethoxam and its amelioration by quercetin on oxidative stress and antioxidant parameters in male rats were conducted. Ninety six (96) adult male rats were divided in 6 groups for 60 and 90 days study, each comprising of 8 rats. Group I was kept as control and received 2% gum acacia. Groups II, III, IV, V, VI were administered with lower dose of TMX (2.5% MTD), higher dose of TMX (5.0% MTD), quercetin (50mg/kg), lower dose of TMX (2.5% MTD) + Qu (50mg/kg) and higher dose of TMX (5.0% MTD) + Qu (50mg/kg), respectively. Oxidative stress parameters such as lipid peroxidation (MDA) and protein carbonyl content (PCC) was seen to have increased and antioxidant parameters such as superoxide dismutase (SOD) and total thiols decreased significantly. Quercetin in this study exhibited amelioration effect by reversing the effect of thiamethoxam on these parameters investigated.

Key words: Subchronic exposure, thiamethoxam, quercetin, oxidative stress, antioxidant parameters.


 
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How to Cite this Article
Pubmed Style

Auwal MS, Vinod K, Salihu SI, Vinay K, Aryan B, . The effect of thiamethoxam and ameliorative property of quercetin on oxidative stress and antioxidant parameters in liver of male rats. JPAS. 2021; 21(1): 10-19. doi:10.5455/sf.62406


Web Style

Auwal MS, Vinod K, Salihu SI, Vinay K, Aryan B, . The effect of thiamethoxam and ameliorative property of quercetin on oxidative stress and antioxidant parameters in liver of male rats. http://www.atbuscienceforum.com/?mno=62406 [Access: May 11, 2021]. doi:10.5455/sf.62406


AMA (American Medical Association) Style

Auwal MS, Vinod K, Salihu SI, Vinay K, Aryan B, . The effect of thiamethoxam and ameliorative property of quercetin on oxidative stress and antioxidant parameters in liver of male rats. JPAS. 2021; 21(1): 10-19. doi:10.5455/sf.62406



Vancouver/ICMJE Style

Auwal MS, Vinod K, Salihu SI, Vinay K, Aryan B, . The effect of thiamethoxam and ameliorative property of quercetin on oxidative stress and antioxidant parameters in liver of male rats. JPAS. (2021), [cited May 11, 2021]; 21(1): 10-19. doi:10.5455/sf.62406



Harvard Style

Auwal, M. S., Vinod, K., Salihu, S. I., Vinay, K., Aryan, B. & (2021) The effect of thiamethoxam and ameliorative property of quercetin on oxidative stress and antioxidant parameters in liver of male rats. JPAS, 21 (1), 10-19. doi:10.5455/sf.62406



Turabian Style

Auwal, Mohammed Shuaibu, Kumar Vinod, Sabo Isa Salihu, Kant Vinay, Bhidhasra Aryan, and . 2021. The effect of thiamethoxam and ameliorative property of quercetin on oxidative stress and antioxidant parameters in liver of male rats. Science Forum (Journal of Pure and Applied Sciences), 21 (1), 10-19. doi:10.5455/sf.62406



Chicago Style

Auwal, Mohammed Shuaibu, Kumar Vinod, Sabo Isa Salihu, Kant Vinay, Bhidhasra Aryan, and . "The effect of thiamethoxam and ameliorative property of quercetin on oxidative stress and antioxidant parameters in liver of male rats." Science Forum (Journal of Pure and Applied Sciences) 21 (2021), 10-19. doi:10.5455/sf.62406



MLA (The Modern Language Association) Style

Auwal, Mohammed Shuaibu, Kumar Vinod, Sabo Isa Salihu, Kant Vinay, Bhidhasra Aryan, and . "The effect of thiamethoxam and ameliorative property of quercetin on oxidative stress and antioxidant parameters in liver of male rats." Science Forum (Journal of Pure and Applied Sciences) 21.1 (2021), 10-19. Print. doi:10.5455/sf.62406



APA (American Psychological Association) Style

Auwal, M. S., Vinod, K., Salihu, S. I., Vinay, K., Aryan, B. & (2021) The effect of thiamethoxam and ameliorative property of quercetin on oxidative stress and antioxidant parameters in liver of male rats. Science Forum (Journal of Pure and Applied Sciences), 21 (1), 10-19. doi:10.5455/sf.62406